Pitolisant is the first of a new class of medicine, a histamine H3‑receptor antagonist/inverse agonist, licensed to treat narcolepsy. In practice the prescribed quantity would need to be a multiple of 180 ml, taking into account that sodium oxybate is a schedule 2 controlled drug and the quantity prescribed should be enough meet the person's clinical needs for no more than 30 days ( Drug Tariff, February 2017 NICE guideline on Controlled drugs: safe use and management). However sodium oxybate is a special container with a pack size of 180 ml, therefore the pack cannot be split. I Lower cost estimate is based on the exact cost for the volume required (270 ml) for a 30‑day supply at a dose of 4.5 g daily. Sodium oxybate is licensed in adults for the treatment of narcolepsy with cataplexy. H From BNF and sodium oxybate summary of product characteristics. Dexamfetamine is licensed for narcolepsy. G From BNF and dexamfetamine summaries of product characteristics. Methylphenidate is not licensed for narcolepsy ( methylphenidate summaries of product characteristics). Modafinil is licensed in adults for the treatment of excessive sleepiness associated with narcolepsy with or without cataplexy.Į Costs taken from Drug Tariff, February 2017 (excluding VAT).į From BNF. Pitolisant is licensed in adults for the treatment of narcolepsy with or without cataplexy.Ĭ Costs taken from MIMS, February 2017 (excluding VAT).ĭ From BNF and modafinil summary of product characteristics. Initially 2.25 g on retiring and repeated 2.5 to 4 hours later, increased according to response in steps of 1.5 g daily in 2 divided doses at intervals of 1 to 2 weeks to a maximum of 9 g daily in 2 divided doses hĪ These directions do not represent the full range that can be used and they do not imply therapeutic equivalence.ī From pitolisant summary of product characteristics. Initially 10 mg (elderly 5 mg) daily in divided doses increased at weekly intervals by 10 mg (elderly 5 mg) daily to a maximum of 60 mg daily g Initially 200 mg (elderly 100 mg) daily, either in 2 divided doses morning and at noon or as a single dose in the morning, adjusted according to response to 200 mg to 400 mg daily in 2 divided doses or as a single dose dġ0 mg to 60 mg (usually 20 mg to 30 mg) daily in divided doses before meals f Cost per 30 days treatment, excluding VAT
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