Pitolisant is the first of a new class of medicine, a histamine H3‑receptor antagonist/inverse agonist, licensed to treat narcolepsy. In practice the prescribed quantity would need to be a multiple of 180 ml, taking into account that sodium oxybate is a schedule 2 controlled drug and the quantity prescribed should be enough meet the person's clinical needs for no more than 30 days ( Drug Tariff, February 2017 NICE guideline on Controlled drugs: safe use and management). However sodium oxybate is a special container with a pack size of 180 ml, therefore the pack cannot be split. I Lower cost estimate is based on the exact cost for the volume required (270 ml) for a 30‑day supply at a dose of 4.5 g daily. Sodium oxybate is licensed in adults for the treatment of narcolepsy with cataplexy. H From BNF and sodium oxybate summary of product characteristics. Dexamfetamine is licensed for narcolepsy. G From BNF and dexamfetamine summaries of product characteristics. Methylphenidate is not licensed for narcolepsy ( methylphenidate summaries of product characteristics). Modafinil is licensed in adults for the treatment of excessive sleepiness associated with narcolepsy with or without cataplexy.Į Costs taken from Drug Tariff, February 2017 (excluding VAT).į From BNF. Pitolisant is licensed in adults for the treatment of narcolepsy with or without cataplexy.Ĭ Costs taken from MIMS, February 2017 (excluding VAT).ĭ From BNF and modafinil summary of product characteristics. Initially 2.25 g on retiring and repeated 2.5 to 4 hours later, increased according to response in steps of 1.5 g daily in 2 divided doses at intervals of 1 to 2 weeks to a maximum of 9 g daily in 2 divided doses hĪ These directions do not represent the full range that can be used and they do not imply therapeutic equivalence.ī From pitolisant summary of product characteristics. Initially 10 mg (elderly 5 mg) daily in divided doses increased at weekly intervals by 10 mg (elderly 5 mg) daily to a maximum of 60 mg daily g Initially 200 mg (elderly 100 mg) daily, either in 2 divided doses morning and at noon or as a single dose in the morning, adjusted according to response to 200 mg to 400 mg daily in 2 divided doses or as a single dose dġ0 mg to 60 mg (usually 20 mg to 30 mg) daily in divided doses before meals f Cost per 30 days treatment, excluding VAT
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There was no indication that any trip would be subsidized by the city or museum. The museum, like many in Europe, is free for student groups. “It is incredibly sought-after by Americans who want to do selfies and enjoy the beauty of this statue,” Director Hollberg said. The statue is the showpiece of the Accademia, and helps draw 1.7 million visitors each year to the museum. Michelangelo Buonarroti sculpted the David between 1501-1504 after being commissioned by the Cathedral of Florence. “The incident is about fear, fear of beauty, of difference, and of the possibilities embedded in art.” “What we have here is a moral crusade against the body, sexuality, and gender expression and an ignorance of history,” Stone said in an email. culture wars and questioned how the statue could be considered so controversial as to warrant a prior warning. Marla Stone, head of humanities studies at the American Academy in Rome, said the Florida incident was another episode in escalating U.S. “I would really have to consider, ‘Is this truly what is best?’” “There’s been such controversy and such upheaval,” she said. Several parents and teachers plan to protest Carrasquilla’s exit at Monday night’s school board meeting, but Carrasquilla said she isn’t sure she would take the job back even if it were offered. “Parents are entitled to know anytime their child is being taught a controversial topic and picture,” Bishop said in an interview with Slate online magazine. He has declined to elaborate, while defending the decision. Ron DeSantis on educational issues.īarney Bishop, chairman of Tallahassee Classical’s school board, has told reporters that while the photo of the statue played a part in Carrasquilla’s ouster, it wasn’t the only factor. It follows a curriculum designed by Hillsdale College, a conservative Christian school in Michigan frequently consulted by Florida Gov. While it is taxpayer-funded and tuition-free, it operates almost entirely independently of the local school district and is sought out by parents seeking an alternative to the public school curriculum.Ībout 400 students from kindergarten through 12th grade attend the three-year-old institution, which is now on its third principal. Tallahassee Classical is a charter school. She invited the principal, school board, parents and student body to view the “purity” of the statue. “To think that David could be pornographic means truly not understanding the contents of the Bible, not understanding Western culture and not understanding Renaissance art,” Hollberg said in a telephone interview. “I’ve been to Florence before and have seen the David up close and in person, but I would love to go and be a guest of the mayor.”Ĭecilie Hollberg, director of the Galleria dell’Accademia, where the David resides, expressed astonishment at the controversy. “I am totally, like, wow,” Carasquilla said. However, ACE recommend the following exercises for building muscle endurance, which a person can perform at home without equipment: PushupĪ pushup works the triceps, chest, and shoulder muscles. The design of a training program makes it suitable for endurance training. Example exercisesĪs we have already mentioned, there are no specific exercises that are better for training muscular endurance than others. People can choose exercises that suit their preferences and are challenging yet enjoyable enough to sustain training. If they have an RM of 300 pounds (lbs), they should aim to perform 2–4 sets of 15 or more reps with a load of 150lbs or less, with brief rest periods between sets.Īs their muscular endurance for this exercise increases, they may wish to make the exercise more challenging by reducing rest times between sets, or increasing the reps per set, rather than increasing the load weight.Ī person can apply the same principle of high rep and set volume, low–moderate load, and short rest periods to any exercise, such as bench presses, dumbbell curls, pushups, or squats. the weight or resistant force on the musclesĪccording to the National Strength and Conditioning Association, individuals training for muscular endurance should aim to complete three or more sets of 15 or more exercise reps with a load that is 50% or less of their one rep max (RM).Ī person’s one rep max is the maximum load with which a person can complete one repetition of an exercise.įor example, a person may wish to use the leg press machine at the gym to build endurance in the legs.People should take into consideration the following when tailoring a workout to boost muscular endurance: When training to improve muscular endurance, what matters most is not the type of exercise, but how people design their workout. Particularly considering that the health benefits of exercise have to be viewed in the context of the likelihood that exercise is continued for several years, not just the weeks of a controlled study.” “Variety in the type of exercise is as important as the type of exercise. Some evidence also suggests that exercise programs that people find enjoyable may be more likely to generate long-term benefits, as they may be more likely to stick with them.Ī 2015 study comparing HIIT and steady-state training notes: The best exercise programs mix strength and muscular endurance training. Unless a person’s fitness goals involve training for a particular endurance-based sport, training for muscular endurance alone may not be the most appropriate strategy. Moderate resistance training, with short intervals in between for rest, creates short bursts of tension to build strength.Ĭircuit or high-intensity interval training (HIIT) can be a suitable way to combine cardio and strength training into one workout. The similar VO 2max in endurance and team athletes and similar jump power in team and power athletes suggest that concurrent training does not necessarily impair power or endurance performance.Īnaerobic capacity Jumping power Maximal oxygen uptake Performance.To increase muscular endurance, ACE recommend a combination of lower and upper body exercises, with strengthening exercises to target the whole body. Power athletes had stronger, but not faster, muscles than endurance athletes. The larger oxygen pulse, without significant differences in stroke volume, in endurance than power athletes indicates a larger oxygen extraction during exercise. Endurance athletes (20.6%) had a higher (p < 0.05) aerobic:anaerobic power ratio than controls and power and team athletes (14.0-15.3%). The higher anaerobic power in power and team athletes than in endurance athletes and non-athletes (p < 0.001) was associated with a larger force (p < 0.001), but not faster contractile properties. Athletes had a larger stroke volume, left ventricular mass and left ventricular wall thickness than non-athletes (p < 0.02), but there were no significant differences between athlete groups. The VO 2max (L min -1) was larger in endurance and team athletes than in power athletes and non-athletes (p < 0.05). Dynamometry and M-mode echocardiography were used to measure muscle strength and stroke volume. Endurance (n = 87 distance runners, road cyclists, paddlers, skiers), power (n = 77 sprinters, throwers, combat sport athletes, body builders), team (n = 64 basketball, soccer, volleyball) and non-athletes (n = 223) performed a countermovement jump and an incremental running test to estimate their maximal anaerobic and aerobic power (VO 2max), respectively. We hypothesized that endurance athletes have lower muscle power than power athletes due to a combination of weaker and slower muscles, while their higher endurance is attributable to better oxygen extraction, reflecting a higher muscle oxidative capacity and larger stroke volume. It’s also crucial to evaluate your own recording needs. For example, not every screen recording application comes with an HD screen recorder.Īs such, you should pay attention to its capabilities before downloading or installing screen recording software on your device. Others may have the capability to do all of that, but might be missing a feature or two. Some screen recording tools can’t save the recorded footage for various formats or export it to popular video platforms like YouTube directly. However, no two screen recording tools are alike. The recording can include everything from your taps and cursor movements to typing a URL into your browser to help people learn what to do and how to do it.Īudio narration is available, and sometimes annotation is also offered as part of a tool’s package. Screen recording software can record the entirety (or portions) of your computer or mobile screen. The 10 best screen recording tools in existence.The difference between desktop and online screen recorder.The features you should look for in screen recording software.Whether you want a more precise way to record the entire screen or if you want to capture a specific portion, a high-quality screen recorder will serve the purpose. If you do any kind of product demonstrations, need or offer tech support, or use video calling, using the default screen capture of your computer won’t be good enough to capture high-quality footage. Nowadays, you can create professional-looking tutorials with minimal effort.īesides tutorials, there are several other reasons why you might want to record your screen. You had to either use complicated tools or pay a software expert to get it done, which wasn’t always feasible.įortunately, the user-friendliness of screen recording software has significantly improved over the years. Recording a screen used to be a real challenge. Enter your Instagram account’s Username and Password, and select Log in. To add an Instagram account to your Page, select Connect Account.To add or remove an Instagram account from your Facebook Page: You must be the admin of the Facebook Page you are trying to connect to Instagram. If you have a personal account, you will be prompted to convert to a business account during the linking process. To create an Instagram account, download the app from your phone and follow the screens for creating a new account. We recommend completing these steps in advance. You must have an existing Instagram business account, a Facebook account and a Facebook Business page attached to your Facebook account. The instructions below will tell you how to connect your Instagram account to your Facebook Business page even if you are not using our WordPress plugin. These instructions were created for those who want to display a business or hashtag feed using our Feed Them Social plugin. NOTE: In our testing and at the time of this article being written, it appears you Instagram Creator Accounts are basically being treated like Instagram Personal Accounts. For that all you have to do is click the the button to get an access token like you normally have when using our plugin. If you don’t mind not showing your profile info such as follower, follow count, bio and a few other things in the profile, plus not being able to see the hear or comment count stats on your posts then you don’t have to worry about connecting your account to facebook or making it a business account. So what are the changes you may be asking? One of the big changes to gain access to your own profile information, hearts and comment counts is that you will now need a Facebook Business Page AND your Instagram must be a Instagram Business Account instead of a Instagram Personal Account. Similar to how Facebook named it’s API – Facebook Graph API. They will now called the Instagram Graph API and Instagram Basic Display API. In a nutshell, Instagram’s API is being absorbed into Facebook’s System. If you haven’t heard yet, Instagram is shutting down their Legacy API. If I'm mistaken here, please let me know in a comment. The latter two points will be true for all the tools and utilities mentioned in the other answers to this question.
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Sculptris is a program for digital sculpting. Because 3D models are visual, it is also less required to translate reams of how-to text for your multinational team members, investors, or clients, making it easier for them to access key design information. Fortunately, 3D CAD modeling makes it much simpler to comply with international codes and standards because each standard’s parameters are incorporated. Language and local standards are significant factors in a global economy. Additionally, 3D artists can modify existing textures or develop new ones from scratch. Experts can replicate rough sketches in 3D, explore freely an object’s geometry, and shape it like clay. It also encourages designers from various engineering disciplines to cooperate on product creation.Īrtists may produce 3D objects with nearly any shape and structure using modern 3D modeling software. 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Indeed, technology is changing in almost every business. 2D and 3D Assets for Virtual Environments.Banking/Financial/Retail Data Processing Services. Just a few years ago, however, Democrats embraced Prout’s cause-an about-face the Prout family says is a betrayal. The Prout family has asked every Democratic senator on the Judiciary Committee to vote against Delaney’s nomination, athough they say they’ve been met with silence. Susan Prout, who cofounded a nonprofit aimed at spreading awareness about sexual assault called I Have the Right To, penned an op-ed arguing against the confirmation of Supreme Court justice Brett Kavanaugh, and campaign finance records reviewed by the Free Beacon show the Prouts gave small donations to a number of Democratic politicians over the years. But they are now pressing Democratic senators and the White House to stay true to Biden’s campaign promise of ensuring "justice for survivors" The effort to kill Delaney’s nomination is not a partisan cause for the Prout family, who describe themselves as apolitical and have a history of supporting Democratic candidates and causes, including participation in the Trump-era Women’s March. So I think they felt very comfortable with this threat and thought if they made it, that we would … roll over."ĭelaney’s successful push to reveal Chessy Prout’s identity became a flashpoint in his hearing before the Senate Judiciary Committee earlier this month, with Republicans arguing that his conduct was unethical and did not even favorably serve his client's interests.ĭelaney testified on Capitol Hill that he never "intended to intimidate any of the parties to the case" and he is asking the Senate to put the incident in context-to " consider the totality of my record over nearly 30 years," he told the panel. "The school already knew that she faced death threats, rape threats from the internet trolls. "The motion that Michael Delaney filed on behalf of St Paul's School was really a veiled threat," said Alex Prout. Delaney represented the Boy Scouts and ultimately prevailed. When the Boy Scouts of America faced a lawsuit from victims of a former scout leader who molested over 100 boys, their names were never made public, though all of the victims were adults at the time of the lawsuit. Keeping victims of sex crimes anonymous at trial is hardly irregular. The school demanded access to Prout’s diary, threatened to interview her friends, and filed a motion to strip her anonymity at trial. Paul’s retained Delaney as counsel, and his tactics were aggressive from the outset. Paul’s filed by the Prouts, in which Chessy Prout-referred to as "Jane Doe"- alleged that the school had tolerated "ritual" sexual abuse by students. That accountability also included a civil suit against St. That settlement stemmed from Chessy Prout’s quest for accountability for that senior, Owen Labrie, who was found guilty in 2015 of misdemeanor sexual assault. Paul’s became one of the only schools in the country to enter into a settlement agreement with law enforcement in order to avoid potential criminal charges over what New Hampshire authorities called rampant "child endangerment," a blemish on the reputation of an institution that counts John Kerry, Robert Mueller, and Sen. "You've chosen the path that you wanted to take to make money off of survivors of sexual assault and defend these institutions." Delaney, you do not deserve to be in this position," Alex Prout said. Sitting alongside his wife, Susan, Alex Prout says that Delaney-having pushed successfully to unmask the identity of his daughter in a civil lawsuit surrounding the elite boarding school’s culpability for her sexual assault at the hands of an 18-year-old high-school senior-does not belong on the federal bench. "This is a time to do the courageous thing and withdraw this nomination," Alex Prout told the Washington Free Beacon. That has left it to the Prout family to make sure, in the words of Chessy’s father Alex Prout, that Delaney is nothing more than "an ambulance-chasing attorney." Jeanne Shaheen (D.)-who once lauded Prout’s transformation from a high-school student into a young activist-are nowhere to be found. Seven of the 11 Democrats on the Senate Judiciary Committee were no-shows for his hearing before the panel earlier this month. And his nomination to the First Circuit Court of Appeals has put Democrats in an awkward spot, caught between support for one of their party’s judicial nominees and support for survivors of sexual assault.įor now, they seem to have opted for the former, despite pleas from Prout’s parents to sink Delaney’s nomination. Now, five years after the Prouts settled with the school, President Joe Biden wants to make Delaney a federal judge. |
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